Welcome
Bordeaux Proteome is a scientific and technological platform open to all academic and private scientific communities through the provision of services, materials and expertise in the field of proteomic analysis.
Based on the most innovative technologies and methodologies and the latest generation instruments, Bordeaux Proteome offers services in protein analysis by mass spectrometry and associated separation techniques.
A complete service offer integrating the identification, characterization and quantification / differential analysis of proteins is offered by the platform.
Since 2015, Bordeaux Proteome has been certified ISO 9001 and NF X 50-900. The certified Quality Management System concerns our activities: Research, technological development and expertise in mass spectrometry and proteomics in the fields of Biology, Health and Agronomy.
Our expertise
- Identification of proteins in complex mixtures.
- Quantitation and measurement of protein differential expression with / without labeling
- Characterization of co/post-translational modifications
- de novo sequencing
- Protein partners identification (Interactomics, protein complexes).
Our services
One facility
One organization
Several activities
Differential proteomics
Biomarkers identification
Interactomics
PTMs modifications
Deep Proteome
Clinical cohorts
Multi-omic analysis (proteins, lipids, polysaccharides)
Trace analysis
Taxonomic identification
de novo sequencing
Protein modifications
Spatial distribution on tissues
multi-omics
multi-modal
Exogeneous compound quantification using MALDI MSI
MSI data processing
Glycosylation profiling
Protein complexes
Protein-protein/ligand interactions
Crosslinking
HDX-MS
Affinity-based protein profiling
LiP-MS (limited proteolysis)
Top-Down MS protein characterization
Our services
| Sample Preparation | Protein and peptide analysis | Data analysis | R&D expertises |
|---|---|---|---|
| For Mass Spectrometry analysis | By high-resolution mass spectrometry | Bio-informatic treatment | The M3S team from CBMN |
| Electrophoretic or chromatographic separation Protein enrichment or depletion Peptide sub-species enrichment (phosphoproteomics, glycosylation …) Various proteolysis solutions: in gel, in solution, multi-enzyme, trace studies … | High resolution MS and nanoLC-MS/MS analyzes (Orbitrap) Fast or resolving chromatographic gradients CID, HCD, ETD, EThcD, UVPD fragmentations | Software and hardware dedicated to identification, quantitation and characterization of proteins Nouveauté 2024: Chimerys, algorithme de recherche en database basé sur l’Intelligence Artificielle (IA) Omics data integration with the CBiB (bioinformatic cenetr from Bordeaux): statistical validation, Go terms enrichment, visualisation tools and result interpretation, proteome functional annotation | Analyse structurale par échange isotopique ou cross-linking: étude conformationnelle, interaction cartographie d’épitopes MSI (Mass Spectrometry Imaging) of lipids, metabolits, peptides/proteins Intact protein analysis by Top-Down MS Glycoproteins / glycopeptides analysis Traces and ultra traces analysis |
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